Critical appraisal:Phoa KN, van Vilsteren FG, Weusten BL, Bisschops R, Schoon EJ, Ragunath K, et al 2014

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Critical Appraisal

Article being appraised

Phoa KN, van Vilsteren FG, Weusten BL, Bisschops R, Schoon EJ, Ragunath K, et al. Radiofrequency ablation vs endoscopic surveillance for patients with Barrett esophagus and low-grade dysplasia: a randomized clinical trial. JAMA 2014 Mar 26;311(12):1209-17 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/24668102.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

136


Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
Moderate risk of bias Comments:

Risk of bias assessment: randomised controlled trial

Was the trial double-blinded?
Outcomes not blinded, substantial side-effects, or not reported.
Was the treatment allocation schedule concealed?
Adequately concealed (e.g. central randomisation, numbered or coded bottles, drugs prepared by pharmacy).
Were all randomised participants included in the analysis?
Exclusions not likely to cause bias (>80% follow-up for all groups, <5% difference in follow-up between groups)
The field below is not considered when calculating the risk of bias rating
How was the allocation schedule generated?
Adequate (e.g. random number table, computer random generator, coin tossing, card shuffling)
Size of effect
1 Reason for decision:
Relevance of evidence
1 Additional comments:
Result of appraisal

Jutta's tick icon.png Included




Completed by

Professor David Watson MBBS, MD, FRACS


Jutta's tick icon.png This appraisal has been completed.


Article
Phoa KN, van Vilsteren FG, Weusten BL, Bisschops R, Schoon EJ, Ragunath K, et al. Radiofrequency ablation vs endoscopic surveillance for patients with Barrett esophagus and low-grade dysplasia: a randomized clinical trial. JAMA 2014 Mar 26;311(12):1209-17 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/24668102.
Assigned to
User:David.watson
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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