Critical appraisal:Price A, Yellowlees A, Keerie C, Russell S, Faivre-Finn C, Gilligan D, et al 2012 1
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This appraisal has been completed.
- Article
- Price A, Yellowlees A, Keerie C, Russell S, Faivre-Finn C, Gilligan D, et al. Radical radiotherapy with or without gemcitabine in patients with early stage medically inoperable non-small cell lung cancer. Lung Cancer 2012 Sep;77(3):532-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/22672970.
- Assigned to
- User:Shawgi.sukumaran
- Topic area
- Guidelines:Lung cancer/Treatment/Non-small-cell stage II inoperable
- Clinical question
- Study design
- randomised controlled trial
- Level of Evidence
- II
Section below only relevant for Cancer Council Project Officer
Critical Appraisal
Article being appraised
Price A, Yellowlees A, Keerie C, Russell S, Faivre-Finn C, Gilligan D, et al. Radical radiotherapy with or without gemcitabine in patients with early stage medically inoperable non-small cell lung cancer. Lung Cancer 2012 Sep;77(3):532-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/22672970.
Applicable clinical question
Key Facts
Study Design
randomised controlled trial
Number of Patients:
Not applicable
Evidence ratings
Level of evidence
II
Result of appraisal
Excluded
Reason for decision
Study looks at Gemcitabine as a radiosensitiser for concurrent chemo-radiotherapy. This is not a standard agent used for this indication plus the study was negative for primary end point and did not have adequate power
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