Critical appraisal:Price A, Yellowlees A, Keerie C, Russell S, Faivre-Finn C, Gilligan D, et al 2012 1

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Article
Price A, Yellowlees A, Keerie C, Russell S, Faivre-Finn C, Gilligan D, et al. Radical radiotherapy with or without gemcitabine in patients with early stage medically inoperable non-small cell lung cancer. Lung Cancer 2012 Sep;77(3):532-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/22672970.
Assigned to
User:Shawgi.sukumaran
Topic area
Guidelines:Lung cancer/Treatment/Non-small-cell stage II inoperable
Clinical question
Form
Form:Critical appraisal
Study design
randomised controlled trial
Level of Evidence
II

Section below only relevant for Cancer Council Project Officer

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Critical Appraisal

Article being appraised

Price A, Yellowlees A, Keerie C, Russell S, Faivre-Finn C, Gilligan D, et al. Radical radiotherapy with or without gemcitabine in patients with early stage medically inoperable non-small cell lung cancer. Lung Cancer 2012 Sep;77(3):532-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/22672970.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

Not applicable



Evidence ratings

Level of evidence

II


Risk of bias assessment: randomised controlled trial

Was the trial double-blinded?
No response
Was the treatment allocation schedule concealed?
No response
Were all randomised participants included in the analysis?
No response
The field below is not considered when calculating the risk of bias rating
How was the allocation schedule generated?
No response
Result of appraisal

Jutta's exclamation mark icon.png Excluded

Reason for decision

Study looks at Gemcitabine as a radiosensitiser for concurrent chemo-radiotherapy. This is not a standard agent used for this indication plus the study was negative for primary end point and did not have adequate power


Completed by

Dr Shawgi Sukumaran