Critical appraisal:Priestman TJ, Dunn J, Brada M, Rampling R, Baker PG 1996

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Critical Appraisal

Article being appraised

Priestman TJ, Dunn J, Brada M, Rampling R, Baker PG. Final results of the Royal College of Radiologists' trial comparing two different radiotherapy schedules in the treatment of cerebral metastases. Clin Oncol (R Coll Radiol) 1996;8(5):308-15 Available from: http://www.ncbi.nlm.nih.gov/pubmed/8934050.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

544


Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
Low risk of bias Comments: Large multicentre RCT. Central randomisation. FU duration not clear. Study powered adequately. Brain mets diagnosed on CT scan.


Size of effect
1 Reason for decision: RCT of two fractionation regimens showing superior survival of 30Gy/10# over 12Gy/2# (median OS 84d vs 77d) No difference in response or toxicity.
Relevance of evidence
1 Additional comments: Survival, response and toxicity reported.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Associate Professor Shalini Vinod MBBS MD FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Priestman TJ, Dunn J, Brada M, Rampling R, Baker PG. Final results of the Royal College of Radiologists' trial comparing two different radiotherapy schedules in the treatment of cerebral metastases. Clin Oncol (R Coll Radiol) 1996;8(5):308-15 Available from: http://www.ncbi.nlm.nih.gov/pubmed/8934050.
Assigned to
User:Shalini.vinod
Topic area
Guidelines:Lung cancer/Treatment/Non-small-cell stage IV inoperable
Clinical question
Form
Form:Critical appraisal


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