Critical appraisal:Reed MF, Tolis G Jr, Edil BH, Allan JS, Donahue DM, Gaissert HA, et al 2005

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Critical Appraisal

Article being appraised

Reed MF, Tolis G Jr, Edil BH, Allan JS, Donahue DM, Gaissert HA, et al. Surgical treatment of esophageal high-grade dysplasia. Ann Thorac Surg 2005 Apr;79(4):1110-5; discussion 1110-5 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/15797034.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

96


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Deals with HGD over a 22 year time period in a single institution with surgery spread over the time and endoscopic therapy recent to 2005. Multiple ET techniques - PDT and EMR. High failure rate of HGD eradication - higher than recent studies.

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No, but objective measures used
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
5 Reason for decision: As above
Relevance of evidence
6 Additional comments: Not possible to rate with this study where selection bias for all therapies and no clear assessment of comparative benefits
Result of appraisal

Jutta's exclamation mark icon.png Excluded

Reason for decision

Essentially an article about surgical treatment of HGD outlining the longitudional treatment which included endotherapy in highly selected patients. No formal comparisons with the two interventions.


Completed by

Associate Professor Bernard Mark Smithers


Jutta's tick icon.png This appraisal has been completed.


Article
Reed MF, Tolis G Jr, Edil BH, Allan JS, Donahue DM, Gaissert HA, et al. Surgical treatment of esophageal high-grade dysplasia. Ann Thorac Surg 2005 Apr;79(4):1110-5; discussion 1110-5 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/15797034.
Assigned to
User:Bernard.smithers
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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