Critical appraisal:Res U, Res P, Kastelic D, Stanovnik M, Kmetec A, Merlo A 2000

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Article
Res U, Res P, Kastelic D, Stanovnik M, Kmetec A, Merlo A. Birth after treatment of a male with seminoma and azoospermia with cryopreserved-thawed testicular tissue. Hum Reprod 2000 Apr;15(4):861-4 Available from: http://www.ncbi.nlm.nih.gov/pubmed/10739833.
Assigned to
User:Rita.upreti
Topic area
Guidelines:COSA:Cancer fertility preservation guidelines/Options for treatment
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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Critical Appraisal

Article being appraised

Res U, Res P, Kastelic D, Stanovnik M, Kmetec A, Merlo A. Birth after treatment of a male with seminoma and azoospermia with cryopreserved-thawed testicular tissue. Hum Reprod 2000 Apr;15(4):861-4 Available from: http://www.ncbi.nlm.nih.gov/pubmed/10739833.


Applicable clinical question

Key Facts

Study Design

case series

Study aims:

Adult case report of open testicular biopsy taken pre-seminoma treatment, cryopreserved and later used for ICSI.

Number of Patients:

1

He was azoospermic before and after three chemo course so this biopsy material was a saviour for him.


They biopsied.... 3x3x3 mmm piece... his normal left tests at the time his right was removed with the tumour .
Reported outcome(s):

Fertilisation
Embryo transfer
Live birth

Results of outcome(s):

Fertilisation: 6 out of 8 fertilised
Embryo transfer: 4x4 cell embryos were transferred
Live birth: Healthy singleton

Comments on results:

Single case from 2000

Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments:


Size of effect
5 Reason for decision:
Relevance of evidence
1 Additional comments:
Result of appraisal

Jutta's tick icon.png Included




Completed by

Professor Robert McLachlan AM FRACP PhD