Critical appraisal:Res U, Res P, Kastelic D, Stanovnik M, Kmetec A, Merlo A 2000
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This appraisal has been completed.
- Article
- Res U, Res P, Kastelic D, Stanovnik M, Kmetec A, Merlo A. Birth after treatment of a male with seminoma and azoospermia with cryopreserved-thawed testicular tissue. Hum Reprod 2000 Apr;15(4):861-4 Available from: http://www.ncbi.nlm.nih.gov/pubmed/10739833.
- Assigned to
- User:Rita.upreti
- Topic area
- Guidelines:COSA:Cancer fertility preservation guidelines/Options for treatment
- Clinical question
Section below only relevant for Cancer Council Project Officer
Critical Appraisal
Article being appraised
Res U, Res P, Kastelic D, Stanovnik M, Kmetec A, Merlo A. Birth after treatment of a male with seminoma and azoospermia with cryopreserved-thawed testicular tissue. Hum Reprod 2000 Apr;15(4):861-4 Available from: http://www.ncbi.nlm.nih.gov/pubmed/10739833.
Applicable clinical question
Key Facts
Study Design
case series
Study aims:
Adult case report of open testicular biopsy taken pre-seminoma treatment, cryopreserved and later used for ICSI.
Number of Patients:
1
He was azoospermic before and after three chemo course so this biopsy material was a saviour for him.
Reported outcome(s):
Fertilisation
Embryo transfer
Live birth
Results of outcome(s):
Fertilisation: 6 out of 8 fertilised
Embryo transfer: 4x4 cell embryos were transferred
Live birth: Healthy singleton
Comments on results:
Single case from 2000
Includes an economic evaluation
no
Evidence ratings
Level of evidence
IV
Risk of bias
| High risk of bias | Comments: |
Size of effect
| 5 | Reason for decision: |
Relevance of evidence
| 1 | Additional comments: |
Result of appraisal
Included
Completed by