Critical appraisal:Rothwell PM, Wilson M, Elwin CE, Norrving B, Algra A, Warlow CP, et al 2010 3

This appraisal is pending.

Article

Rothwell PM, Wilson M, Elwin CE, Norrving B, Algra A, Warlow CP, et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 2010 Nov 20;376(9754):1741-50 Available from: http://www.ncbi.nlm.nih.gov/pubmed/20970847.

Assigned to

User:Priyashiel.parikh

Topic area

Guidelines:Colorectal cancer

Clinical question

• PPR1: What is the risk-benefit ratio for use of aspirin for prevention of colorectal cancer stratified by risk of colorectal cancer itself? (What is the optimal dose and frequency of administration?)

Form

Form:Quality appraisal rct-cochrane

Outcomes

CRC mortality

Clinical trial

Clinical trial:TPT Trial

Notes

Critically appraise the long term follow up for the TPT Trial. Original trial data publication http://wiki.cancer.org.au/australia/Citation:Meade_TW,_Wilke_HC,_Kelleher_CC,_Roderick_PJ,_Brennan_PJ,_Wilson_CW,_et_al_1998

Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment