Critical appraisal:Rugge M, Zaninotto G, Parente P, Zanatta L, Cavallin F, Germanà B, et al 2012 4

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Critical Appraisal

Article being appraised

Rugge M, Zaninotto G, Parente P, Zanatta L, Cavallin F, Germanà B, et al. Barrett's esophagus and adenocarcinoma risk: the experience of the North-Eastern Italian Registry (EBRA). Ann Surg 2012 Nov;256(5):788-94; discussion 794-5. doi: 10.1097/SLA.0b013e3182737a7e. Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/23095623.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

841



Evidence ratings

Risk of bias
High risk of bias Comments: This manuscript describes a registry established in north-eastern Italy in 2003. Details about source population, patient selection and referral were not provided. 439 patients out of 1297 on the register did not have follow-up. Biopsy procedures followed the Seattle protocol.

Risk of bias assessment: prevalence and incidence study

Source population of patients
Selected group (multiple institutions)
Subject (sample) selection
Highly selected (selection at clinician's discretion regardless of whether sample consecutive), unclear or not described
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
No or not described
Result of appraisal

Jutta's tick icon.png Included



Comments

7.3% of patients reverted to normal oesophageal mucosa, and this occurred at the same rate for SSBE and LSBE patients.
Incidence of progression = 0.72 / 100 pyar
On multivariate analyses, risk factors were :
nodularity/ulceration RR 7.60
BE length (per cm) RR 1.17
LGD RR 3.41

Completed by

David Whiteman


Jutta's tick icon.png This appraisal has been completed.


Article
Rugge M, Zaninotto G, Parente P, Zanatta L, Cavallin F, Germanà B, et al. Barrett's esophagus and adenocarcinoma risk: the experience of the North-Eastern Italian Registry (EBRA). Ann Surg 2012 Nov;256(5):788-94; discussion 794-5. doi: 10.1097/SLA.0b013e3182737a7e. Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/23095623.
Assigned to
User:Philip.craig
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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