Critical appraisal:Sánchez A, Reza M, Blasco JA, Callejo D 2010 3

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Critical Appraisal

Article being appraised

Sánchez A, Reza M, Blasco JA, Callejo D. Effectiveness, safety, and cost-effectiveness of photodynamic therapy in Barrett's esophagus: a systematic review. Dis Esophagus 2010 Nov;23(8):633-40 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/20545970.


Applicable clinical question

Key Facts

Study Design

systematic review — 8 RCT's of PTD for Barrett's and 4 economic assessments. Mixture of patients with HGD, LGD, NDBE - total number below

Number of Patients:

432


Includes an economic evaluation

yes

Evidence ratings

Level of evidence

I

Risk of bias
Moderate risk of bias Comments: Useful review article of the studies on PDT. Not possible to make any conclusion specifically regarding LGD

Risk of bias assessment: systematic review

Studies included in the review
Was an adequate search strategy used?
Adequate – search terms and/or choice of databases could have been improved upon
Were the inclusion criteria appropriate and applied in an unbiased way?
Yes – pre-specified inclusion criteria applied independently by two people
Were the studies assessed for quality (relating to the minimisation of biases)?
Adequate – some problems with quality issues or assessed by one person only
Were the characteristics and results of individual studies appropriately summarised?
Yes – summary descriptive tables of subjects, interventions, outcomes etc are provided and estimates of treatment effect displayed
The following questions are only relevant for systematic reviews that pooled data
Were the methods used for pooling the data appropriate?
No response
If there was heterogeneity, were sources of heterogeneity explored?
No response
Size of effect
1 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
2 Additional comments: responses of BE to PDT v APC or v PPI summarised. Clinically relevant responses.
Result of appraisal

Jutta's tick icon.png Included



Comments

Useful review article of the studies on PDT. Not possible to make any conclusion specifically regarding LGD. Includes useful data on responses to PDT and RFA

Completed by

Dr Andrew Taylor MBBS MD FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
Sánchez A, Reza M, Blasco JA, Callejo D. Effectiveness, safety, and cost-effectiveness of photodynamic therapy in Barrett's esophagus: a systematic review. Dis Esophagus 2010 Nov;23(8):633-40 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/20545970.
Assigned to
User:Andrew.taylor
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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