Critical appraisal:Schoen RE, Razzak A, Yu KJ, Berndt SI, Firl K, Riley TL, et al 2015

Risk of bias assessment: cohort study

Subject selection

"New technology" group

Representative of eligible patients.

Comparison group

Representative of eligible patients

Comparability of groups on demographic characteristics and clinical features

Comparable

Measurement of outcomes

Outcome measures blind to technology used

No, but objective measures used

Same method of measurement used across comparison groups

Yes

Completeness of follow-up

Was follow-up complete and were all patients included in the analysis?

Yes (follow-up >95%) or survival analysis using all patients

Overall risk of bias

Low risk of bias

Additional comments: Blinding only occurred for death, not incidence of cancer etc. Median length of follow up was reported (12.5 risk FH, 11.8 no risk)

This appraisal has been completed.

Article

Schoen RE, Razzak A, Yu KJ, Berndt SI, Firl K, Riley TL, et al. Incidence and mortality of colorectal cancer in individuals with a family history of colorectal cancer. Gastroenterology 2015 Nov;149(6):1438-1445.e1 Available from: http://www.ncbi.nlm.nih.gov/pubmed/26255045.

Assigned to

User:Verity.chadwick

Topic area

Guidelines:Colorectal cancer

Clinical question

• FHS2: What is the strength of association between family history and colorectal cancer risk and how do these associations vary by, number of affected relatives and degree of relatedness and age and sex of affected relatives and by the age and sex of the at-risk person?

Form

Form:Quality appraisal cohort

Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment