Critical appraisal:Serizawa I, Kagei K, Kamada T, Imai R, Sugahara S, Okada T, et al 2009

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Critical Appraisal

Article being appraised

Serizawa I, Kagei K, Kamada T, Imai R, Sugahara S, Okada T, et al. Carbon ion radiotherapy for unresectable retroperitoneal sarcomas. Int J Radiat Oncol Biol Phys 2009 Nov 15;75(4):1105-10 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19467578.


Applicable clinical question

Key Facts

Study Design

case series

Number of Patients:

24


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: Single institution case series about Carbon Ion Therapy in management of unresectable Retroperitoneal Sarcomas.

Risk of bias assessment: case series

Subject selection:
Highly selected or not described (e.g. single-institution study)
Were the outcome measures blind to pre/post-intervention?
No or not described
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Size of effect
5 Reason for decision: Non Comparative study, but when compared to published literature this rate of control is excellent.
Relevance of evidence
1 Additional comments: Local Control at 2 and 5 years reported. 5 year local control of 69% for this unresectable group is excellent.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Sarat Chander FRANZCR


Jutta's tick icon.png This appraisal has been completed.


Article
Serizawa I, Kagei K, Kamada T, Imai R, Sugahara S, Okada T, et al. Carbon ion radiotherapy for unresectable retroperitoneal sarcomas. Int J Radiat Oncol Biol Phys 2009 Nov 15;75(4):1105-10 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19467578.
Assigned to
User:Sarat.chander
Topic area
Guidelines:Sarcoma
Clinical question
Form
Form:Critical appraisal


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