Critical appraisal:Shaheen NJ, Crosby MA, Bozymski EM, Sandler RS 2000

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Critical Appraisal

Article being appraised

Shaheen NJ, Crosby MA, Bozymski EM, Sandler RS. Is there publication bias in the reporting of cancer risk in Barrett's esophagus? Gastroenterology 2000 Aug;119(2):333-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/10930368.


Applicable clinical question

Key Facts

Study Design

systematic review — Mainly prevalence and incidence studies or cohort studies.

Number of Patients:

2590


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: systematic review

Studies included in the review
Was an adequate search strategy used?
Very thorough – included appropriate search terms and databases
Were the inclusion criteria appropriate and applied in an unbiased way?
Yes – pre-specified inclusion criteria applied independently by two people
Were the studies assessed for quality (relating to the minimisation of biases)?
No – quality assessment either not undertaken, inappropriate or not described
Were the characteristics and results of individual studies appropriately summarised?
Adequate – more information would be desirable
The following questions are only relevant for systematic reviews that pooled data
Were the methods used for pooling the data appropriate?
No response
If there was heterogeneity, were sources of heterogeneity explored?
No response
Result of appraisal

Jutta's tick icon.png Included



Comments

A total of 25 articles were included, 2590 patients with BO, 87 developed esophageal adenocarcinoma. In studies reporting the incidence of adenocarcinoma of the esophagus in the setting of BO, there is a strong inverse relationship between the size of the study and cancer risk.

Completed by

Ms Qingwei Luo


Jutta's tick icon.png This appraisal has been completed.


Article
Shaheen NJ, Crosby MA, Bozymski EM, Sandler RS. Is there publication bias in the reporting of cancer risk in Barrett's esophagus? Gastroenterology 2000 Aug;119(2):333-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/10930368.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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