Critical appraisal:Sharma P, Falk GW, Weston AP, Reker D, Johnston M, Sampliner RE 2006

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Critical Appraisal

Article being appraised

Sharma P, Falk GW, Weston AP, Reker D, Johnston M, Sampliner RE. Dysplasia and cancer in a large multicenter cohort of patients with Barrett's esophagus. Clin Gastroenterol Hepatol 2006 May;4(5):566-72 Available from: http://www.ncbi.nlm.nih.gov/pubmed/16630761.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

618



Evidence ratings

Risk of bias
Moderate risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: prevalence and incidence study

Source population of patients
Selected group (multiple institutions)
Subject (sample) selection
Selected group (debateable whether group is representative e.g. consecutive sample but extensive exclusion criteria)
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Result of appraisal

Jutta's tick icon.png Included



Comments

A multicentre study, 618 patients with BO were followed for a total of 2546 patient-years (mean FUP 4.12 yrs), 12 patients developed cancer during FUP, cancer incidence of 1 in 212 patient-years of FUP.
Information based on abstract only.

Completed by

Ms Qingwei Luo


Jutta's tick icon.png This appraisal has been completed.


Article
Sharma P, Falk GW, Weston AP, Reker D, Johnston M, Sampliner RE. Dysplasia and cancer in a large multicenter cohort of patients with Barrett's esophagus. Clin Gastroenterol Hepatol 2006 May;4(5):566-72 Available from: http://www.ncbi.nlm.nih.gov/pubmed/16630761.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

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