Critical appraisal:Sikkema M, de Jonge PJ, Steyerberg EW, Kuipers EJ 2010

From Clinical Guidelines Wiki

Critical Appraisal

Article being appraised

Sikkema M, de Jonge PJ, Steyerberg EW, Kuipers EJ. Risk of esophageal adenocarcinoma and mortality in patients with Barrett's esophagus: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2010 Mar;8(3):235-44; quiz e32 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19850156.


Applicable clinical question

Key Facts

Study Design

systematic review — Cohort studies

Number of Patients:

14109


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
Low risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: systematic review

Studies included in the review
Was an adequate search strategy used?
Very thorough – included appropriate search terms and databases
Were the inclusion criteria appropriate and applied in an unbiased way?
Yes – pre-specified inclusion criteria applied independently by two people
Were the studies assessed for quality (relating to the minimisation of biases)?
Yes – appropriate quality issues were assessed independently by two people
Were the characteristics and results of individual studies appropriately summarised?
Yes – summary descriptive tables of subjects, interventions, outcomes etc are provided and estimates of treatment effect displayed
The following questions are only relevant for systematic reviews that pooled data
Were the methods used for pooling the data appropriate?
Yes
If there was heterogeneity, were sources of heterogeneity explored?
Yes
Result of appraisal

Jutta's tick icon.png Included



Comments

Fifty studies reported the incidence of EAC, in total 14109 patients follwed for 61804 person-years and 344 incident EACs developed. Pooled EAC estimate of 6.3/1000 pyrs (4.9-8.2).

Completed by

Ms Qingwei Luo


Jutta's tick icon.png This appraisal has been completed.


Article
Sikkema M, de Jonge PJ, Steyerberg EW, Kuipers EJ. Risk of esophageal adenocarcinoma and mortality in patients with Barrett's esophagus: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 2010 Mar;8(3):235-44; quiz e32 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/19850156.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment