Critical appraisal:Spechler SJ, Robbins AH, Rubins HB, Vincent ME, Heeren T, Doos WG, et al 1984
From Cancer Guidelines Wiki
Critical Appraisal
Article being appraised
Spechler SJ, Robbins AH, Rubins HB, Vincent ME, Heeren T, Doos WG, et al. Adenocarcinoma and Barrett's esophagus. An overrated risk? Gastroenterology 1984 Oct;87(4):927-33 Available from: http://www.ncbi.nlm.nih.gov/pubmed/6468881.
Applicable clinical question
Key Facts
Study Design
prevalence and incidence study
Number of Patients:
115
Evidence ratings
Risk of bias
| High risk of bias | Comments: Please replace this text and include any additional comments in regards to your quality rating |
Result of appraisal
Included
Comments
Completed by
This appraisal has been completed.
- Article
- Spechler SJ, Robbins AH, Rubins HB, Vincent ME, Heeren T, Doos WG, et al. Adenocarcinoma and Barrett's esophagus. An overrated risk? Gastroenterology 1984 Oct;87(4):927-33 Available from: http://www.ncbi.nlm.nih.gov/pubmed/6468881.
- Assigned to
- User:Freddy.sitas
- Topic area
- Guidelines:Barrett's
- Clinical question
Section below only relevant for Cancer Council Project Officer
The risk of developing esophageal cancer in Barrett's esophagus has been estimated at about 10%.We have reviewed retrospectively our experience with 115 patients whom we treated for Barrett's esophagus between September 1962 and March 1983.For 8 patients, we found both Barrett's esophagus and esophageal adenocarcinoma during the initial evaluations for a prevalence ratio of 7%. We followed 105 patients not found to have esophageal cancer initially for a total of 350 person-years. Only 2 patients developed adenocarcinoma during that follow-up period for an incidence of 1 case per 175 person-years. This incidence, although some 40-fold greater than that of the general population, is substantially lower than previously estimated.