Critical appraisal:Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X, et al 2012
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Critical Appraisal
Article being appraised
Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X, et al. Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol 2012 Feb 1;30(4):419-25 Available from: http://www.ncbi.nlm.nih.gov/pubmed/22203767.
Applicable clinical question
Key Facts
Study Design
case series
Number of Patients:
1833
Includes an economic evaluation
no
Evidence ratings
Level of evidence
IV
Risk of bias
| High risk of bias | Comments: Study to evaluate factors predictive of survival in patients with brain metastases following a variety of treatments. Multiple primary tumour sites but 1833 NSCLC patients include. |
Size of effect
| 1 | Reason for decision: Study evaluating factors predictive of survival based on patient and tumour factors. P values and 95% CI given for survival by treatment. |
Relevance of evidence
| 1 | Additional comments: Evaluation of factors predictive of survival in patients with brain metastases |
Result of appraisal
Included
Comments
Completed by
This appraisal has been completed.
- Article
- Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X, et al. Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. J Clin Oncol 2012 Feb 1;30(4):419-25 Available from: http://www.ncbi.nlm.nih.gov/pubmed/22203767.
- Assigned to
- User:Shalini.vinod
- Topic area
- Guidelines:Lung cancer
- Clinical question
Section below only relevant for Cancer Council Project Officer
Although low quality evidence this study is important in providing a prognostic model on which to help base treatment decisions for NSCLC patients with brain metastases.