Critical appraisal:Strom T, Caudell JJ, Han D, Zager JS, Yu D, Cruse CW, et al 2014 3

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Critical Appraisal

Article being appraised

Strom T, Caudell JJ, Han D, Zager JS, Yu D, Cruse CW, et al. Radiotherapy influences local control in patients with desmoplastic melanoma. Cancer 2014 May 1;120(9):1369-78 Available from: http://www.ncbi.nlm.nih.gov/pubmed/24142775.


Applicable clinical question

Key Facts

Study Design

cohort study

Study aims:

To review our experience with radiotherapy in patients with desmoplastic melanoma to analyse the impact of adjuvant postoperative radiotherapy on local recurrence rates.

Number of Patients:

332

332 patients with DM.
194 patients underwent sentinel lymph node biopsy.
Reported outcome(s):

rate of sentinel lymph node biopsy

Results of outcome(s):

28/194 patients were positive for mets (14%).

Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your risk of bias rating

Risk of bias assessment: cohort study

Subject selection
"New technology" group
Highly selected or not described
Comparison group
Highly selected or not described
Comparability of groups on demographic characteristics and clinical features
Not comparable and not adjusted for differences
Measurement of outcomes
Outcome measures blind to technology used
No, but objective measures used
Same method of measurement used across comparison groups
Yes
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
Yes (follow-up >95%) or survival analysis using all patients
Size of effect
5 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
2 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

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Completed by

Cecilia Taing


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Article
Strom T, Caudell JJ, Han D, Zager JS, Yu D, Cruse CW, et al. Radiotherapy influences local control in patients with desmoplastic melanoma. Cancer 2014 May 1;120(9):1369-78 Available from: http://www.ncbi.nlm.nih.gov/pubmed/24142775.
Assigned to
User:Cecilia.taing
Topic area
Guidelines:Melanoma
Clinical question
Form
Form:Critical appraisal


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