Critical appraisal:Su HI, Sammel MD, Green J, Velders L, Stankiewicz C, Matro J, et al 2010

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Critical Appraisal

Article being appraised

Su HI, Sammel MD, Green J, Velders L, Stankiewicz C, Matro J, et al. Antimullerian hormone and inhibin B are hormone measures of ovarian function in late reproductive-aged breast cancer survivors. Cancer 2010 Feb 1;116(3):592-9 Available from: http://www.ncbi.nlm.nih.gov/pubmed/19918920.


Applicable clinical question

Key Facts

Study Design

cohort study

Study aims:

Premenopuasl breast cancer patients enrolled postchemotherapy and observed.
The primary endpoint was chemotherapy-related amenorrhea (CRA) (> or = 12 months of amenorrhea after chemotherapy). Matched pair analyses compared AMH, inhibin B, and follicle-stimulating hormone (FSH) levels between cancer and age-matched control subjects. Associations between hormones, CRA status, and change in CRA status over time were assessed.

Number of Patients:

127

127 cases matched to 127 controls
Reported outcome(s):

AMH, inhibin B, and follicle-stimulating hormone (FSH) levels between cancer and age-matched control subjects. Associations between hormones, CRA status, and change in CRA status over time were assessed.

Results of outcome(s):

The median age of the patients at chemotherapy was 43.2 years (range, 26.7-57.8 years). At enrollment, median follow-up since chemotherapy was 2.1 years, and 55% of subjects had CRA. Compared with age-matched controls, cancer subjects had significantly lower AMH (P = .004) and inhibin B (P < .001) and higher FSH (P < .001). AMH (P = .002) and inhibin B (P = .001) were found to be significantly associated with risk of CRA, even after controlling for FSH. AMH was significantly lower (P = .03) and FSH was significantly higher (P = .04) in menstruating subjects who developed subsequent CRA

Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
Moderate risk of bias Comments: matched patients used 1-1
Result of appraisal

Jutta's tick icon.png Included



Comments

not a great study but further demonstrates negative effect of chemotherapy

Completed by

Dr Jessica Harris

Jutta's tick icon.png This appraisal has been completed.


Article
Su HI, Sammel MD, Green J, Velders L, Stankiewicz C, Matro J, et al. Antimullerian hormone and inhibin B are hormone measures of ovarian function in late reproductive-aged breast cancer survivors. Cancer 2010 Feb 1;116(3):592-9 Available from: http://www.ncbi.nlm.nih.gov/pubmed/19918920.
Assigned to
User:Roger.hart
Topic area
Guidelines:COSA:Cancer fertility preservation guidelines/Impact of cancer on fertility
Clinical question
Form
Form:Critical appraisal


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