Critical appraisal:Switzer-Taylor V, Schlup M, Lübcke R, Livingstone V, Schultz M 2008 3

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Critical Appraisal

Article being appraised

Switzer-Taylor V, Schlup M, Lübcke R, Livingstone V, Schultz M. Barrett's esophagus: a retrospective analysis of 13 years surveillance. J Gastroenterol Hepatol 2008 Sep 1;23(9):1362-7 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/18205769.


Applicable clinical question

Key Facts

Study Design

other — Retrospective case series, based on systematic review of hospital records.

Number of Patients:

536


Includes an economic evaluation

no

Evidence ratings

Level of evidence

IV

Risk of bias
High risk of bias Comments: This retrospective case series identified 536 patients with BE, of whom 212 were followed up through a hospital-based surveillance program. Information on other confounders was very limited and abstracted from hospital records. Statistical analyses involved comparisons of means and proportions.
Size of effect
1 Reason for decision: Some statistically significant differences observed between those who progressed to cancer and those who did not, including:


Segment length difference in means 3.04 (0.9805.10)
Proportion with ulcer/dysplasia 0.89 vs 0.39

Relevance of evidence
6 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

Jutta's tick icon.png Included



Comments

Small study with weak design, but generally consistent findings.

Completed by

David Whiteman


Jutta's tick icon.png This appraisal has been completed.


Article
Switzer-Taylor V, Schlup M, Lübcke R, Livingstone V, Schultz M. Barrett's esophagus: a retrospective analysis of 13 years surveillance. J Gastroenterol Hepatol 2008 Sep 1;23(9):1362-7 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/18205769.
Assigned to
User:Henry.to
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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