Critical appraisal:Taioli E, Lee DS, Lesser M, Flores R 2013

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Critical Appraisal

Article being appraised

Taioli E, Lee DS, Lesser M, Flores R. Long-term survival in video-assisted thoracoscopic lobectomy vs open lobectomy in lung-cancer patients: a meta-analysis. Eur J Cardiothorac Surg 2013 Feb 14 Available from: http://www.ncbi.nlm.nih.gov/pubmed/23413015.


Applicable clinical question

Key Facts

Study Design

systematic review

Study aims:

To determine if there are differences in long term survival rates after VATS lobectomy versus Thoracotomy lobectomy

Number of Patients:

4767

Reported outcome(s):

5-year post-operative mortality rate

Results of outcome(s):

5-year survival advantage of 5% for patients receiving VATS lobectomy (CI:3-6%)

Comments on results:

Significant heterogeneity between studies, but no publication bias by funnel plot

Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: systematic review

Studies included in the review
Was an adequate search strategy used?
Very thorough – included appropriate search terms and databases
Were the inclusion criteria appropriate and applied in an unbiased way?
No – inclusion was decided in an arbitrary fashion or not described
Were the studies assessed for quality (relating to the minimisation of biases)?
No – quality assessment either not undertaken, inappropriate or not described
Were the characteristics and results of individual studies appropriately summarised?
Yes – summary descriptive tables of subjects, interventions, outcomes etc are provided and estimates of treatment effect displayed
The following questions are only relevant for systematic reviews that pooled data
Were the methods used for pooling the data appropriate?
Yes
If there was heterogeneity, were sources of heterogeneity explored?
No
Size of effect
1 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
1 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

Jutta's tick icon.png Included




Completed by

Associate Professor Gavin Wright MD FRACS PhD


Jutta's tick icon.png This appraisal has been completed.


Article
Taioli E, Lee DS, Lesser M, Flores R. Long-term survival in video-assisted thoracoscopic lobectomy vs open lobectomy in lung-cancer patients: a meta-analysis. Eur J Cardiothorac Surg 2013 Feb 14 Available from: http://www.ncbi.nlm.nih.gov/pubmed/23413015.
Assigned to
User:Gavin.wright
Topic area
Guidelines:Lung cancer/Treatment/Non-small-cell stage I operable
Clinical question
Form
Form:Critical appraisal
Study design
systematic review
Level of Evidence
III-2

Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment