Critical appraisal:Taketani K, Tokunaga E, Yamashita N, Tanaka K, Akiyoshi S, Okada S, et al 2014

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Article
Taketani K, Tokunaga E, Yamashita N, Tanaka K, Akiyoshi S, Okada S, et al. Early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer patients. Surg Today 2014 Oct;44(10):1841-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/24142101.
Assigned to
User:Jessica.harris
Topic area
Guidelines:COSA:Cancer fertility preservation guidelines/Preconception assessment for cancer survivors
Clinical question
Form
Form:Critical appraisal
Study design
cohort study
Level of Evidence
III-2

Section below only relevant for Cancer Council Project Officer

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Critical Appraisal

Article being appraised

Taketani K, Tokunaga E, Yamashita N, Tanaka K, Akiyoshi S, Okada S, et al. Early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer patients. Surg Today 2014 Oct;44(10):1841-6 Available from: http://www.ncbi.nlm.nih.gov/pubmed/24142101.


Applicable clinical question

Key Facts

Study Design

cohort study

Number of Patients:

Not applicable

Results of outcome(s):

The completion rate was 90.6 %. The primary
reason for discontinuing hormone therapy within 5 years
was side effects, such as arthritic pain. The primary factor
related to early discontinuation was a significantly younger
age. The relapse-free survival rate was significantly lower
in the discontinuation group (p = 0.025).


Evidence ratings

Level of evidence

III-2

Risk of bias
Moderate risk of bias Comments:
Result of appraisal

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