Critical appraisal:Taylor GW, Jayne DG, Brown SR, Thorpe H, Brown JM, Dewberry SC, et al 2010
From Cancer Guidelines Wiki
Risk of bias assessment: Randomised Controlled Trial (Cochrane risk of bias tool)
Random sequence generation
Describe the method used to generate the allocation sequence in sufficient detail to allow an assessment of whether it should produce comparable groups.
- Randomisation was stratified by surgeon, proposed site of operation, presence of liver metastases, and preoperative radiotherapy administration; this process was done by telephone by the trial coordinator at the Clinical Trials Research Unit, University of Leeds, Leeds, UK.
What was the risk of bias from the random sequence generation?
- Unclear
Allocation concealment
Describe the method used to conceal the allocation sequence in sufficient detail to determine whether intervention allocations could have been foreseen in advance of or during, enrolment.
- Concealment not described.
What was the risk of bias from the allocation concealment?
- Low
Blinding
Describe all measures used, if any, to blind outcome assessors from knowledge of which intervention a participant received. Provide any information relating to whether the intended blinding was effective.
- Blinding not described.
What was the risk of bias from the blinding of participants and personnel and outcome assessors?
- High
Incomplete outcome data
Describe the completeness of outcome data for each main outcome, including attrition and exlusions from the analysis. State whether attrition and exclusions were reported, the numbers in each intervention group (compared with total randomized participants), reasons for attrition/exclusions where reported, and any re-inclusions in analyses performed by the review authors.
- Missing data not described.
What was the risk of bias from incomplete outcome data?
- Unclear
Selective outcome reporting
State how the possibility of selective outcome reporting was examined by the review authors and what was found.
- Long term complication not described as an outcome.
What was the risk of bias from selective outcome reporting? Assessments should be made for each main outcome (or class of outcomes).
- High
Other sources of bias
Describe any other sources of bias
- Surgeons in laparoscopic group has an early learning curve requiring them to have operated on only 20 or more patients resulting in a high conversion rate. Many participants excluded in comparison to original CLASICC sample
What was the risk of bias from other sources?
- High
Overall risk of bias
| Unclear risk of bias | Additional comments: Please replace this text and include any additional comments in regards to your risk of bias rating |
This appraisal has been completed.
- Article
- Taylor GW, Jayne DG, Brown SR, Thorpe H, Brown JM, Dewberry SC, et al. Adhesions and incisional hernias following laparoscopic versus open surgery for colorectal cancer in the CLASICC trial. Br J Surg 2010 Jan;97(1):70-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/20013936.
- Assigned to
- User:Ben.lee-bates
- Topic area
- Guidelines:Colorectal cancer
- Clinical question
- Form
- Form:Quality appraisal rct-cochrane
- Outcomes
- Long term complications
Section below only relevant for Cancer Council Project Officer