Critical appraisal:Thomas T, Abrams KR, De Caestecker JS, Robinson RJ 2007

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Critical Appraisal

Article being appraised

Thomas T, Abrams KR, De Caestecker JS, Robinson RJ. Meta analysis: Cancer risk in Barrett's oesophagus. Aliment Pharmacol Ther 2007 Dec;26(11-12):1465-77 Available from: http://www.ncbi.nlm.nih.gov/pubmed/17900269.


Applicable clinical question

Key Facts

Study Design

systematic review — Retrospective and prospective cohort studies

Number of Patients:

11387


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: systematic review

Studies included in the review
Was an adequate search strategy used?
Very thorough – included appropriate search terms and databases
Were the inclusion criteria appropriate and applied in an unbiased way?
Yes – pre-specified inclusion criteria applied independently by two people
Were the studies assessed for quality (relating to the minimisation of biases)?
No – quality assessment either not undertaken, inappropriate or not described
Were the characteristics and results of individual studies appropriately summarised?
Yes – summary descriptive tables of subjects, interventions, outcomes etc are provided and estimates of treatment effect displayed
The following questions are only relevant for systematic reviews that pooled data
Were the methods used for pooling the data appropriate?
Yes
If there was heterogeneity, were sources of heterogeneity explored?
Yes
Result of appraisal

Jutta's tick icon.png Included



Comments

There were 11387 patients with BO from 41 studies, total fUP in pyd was 36635 (range 55-11068). Cancer incidence was 7/1000(6-9) person-years duration of FUP.

Completed by

Ms Qingwei Luo


Jutta's tick icon.png This appraisal has been completed.


Article
Thomas T, Abrams KR, De Caestecker JS, Robinson RJ. Meta analysis: Cancer risk in Barrett's oesophagus. Aliment Pharmacol Ther 2007 Dec;26(11-12):1465-77 Available from: http://www.ncbi.nlm.nih.gov/pubmed/17900269.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment