Critical appraisal:Thrift AP, Pandeya N, Smith KJ, Green AC, Hayward NK, Webb PM, et al 2012

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Critical Appraisal

Article being appraised

Thrift AP, Pandeya N, Smith KJ, Green AC, Hayward NK, Webb PM, et al. Helicobacter pylori infection and the risks of Barrett's oesophagus: a population-based case-control study. Int J Cancer 2012 May 15;130(10):2407-16 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21681741.


Applicable clinical question

Key Facts

Study Design

case-control study

Number of Patients:

710


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-3

Risk of bias
High risk of bias Comments: Although the summary evidence rating is low, this is a high-quality observational epidemiological study. The low score reflects the low response rate.

Risk of bias assessment: case-control study

Subject selection
Cases
Representative of eligible patients (e.g. population-based cancer registry)
Adequacy of case definition
Independent validation of outcome (blind to exposure status)
Controls
From same population as cases and same exclusion criteria used
Comparability of groups on demographic characteristics and important potential confounders
Not comparable but adjusted analysis used
Ascertainment of exposure/treatment
Blinded to case/control status
Follow-up complete and all patients included in the analysis?
Low response rate (<80%), non-responders not described, differential response in cases/controls, or no details provided
Size of effect
1 Reason for decision:
Relevance of evidence
1 Additional comments: This population-based case-control study constitutes level III evidence. The study incorporates clinically relevant outcomes.
Result of appraisal



Comments

ODDS RATIO : HELICOBACTER PYLORI
SIMPLE BARRETTS
HP -VE 1.00 (Referent)
HP +VE 0.66 (0.37–1.17)

DYSPLASTIC BARRETTS
HP -VE 1.00 (Referent)
HP +VE 0.13 (0.04–0.45)

ALL CASES
HP -VE 1.00 (Referent)
HP +VE 0.47 (0.27–0.81)

Completed by

David Whiteman


Jutta's tick icon.png This appraisal has been completed.


Article
Thrift AP, Pandeya N, Smith KJ, Green AC, Hayward NK, Webb PM, et al. Helicobacter pylori infection and the risks of Barrett's oesophagus: a population-based case-control study. Int J Cancer 2012 May 15;130(10):2407-16 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21681741.
Assigned to
User:David.whiteman
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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