Critical appraisal:Van Vilsteren FG, Pouw RE, Seewald S, Alvarez Herrero L, Sondermeijer CM, Visser M, et al 2011

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Critical Appraisal

Article being appraised

van Vilsteren FG, Pouw RE, Seewald S, Alvarez Herrero L, Sondermeijer CM, Visser M, et al. Stepwise radical endoscopic resection versus radiofrequency ablation for Barrett's oesophagus with high-grade dysplasia or early cancer: a multicentre randomised trial. Gut 2011 Jun;60(6):765-73 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21209124.


Applicable clinical question

Key Facts

Study Design

case-control study

Number of Patients:

47


Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: case-control study

Subject selection
Cases
Selected group (e.g. multi-institution study)
Adequacy of case definition
Taken from medical records, self report without independent validation
Controls
Selected group (e.g. hospital controls)
Comparability of groups on demographic characteristics and important potential confounders
Comparable (or matched)
Ascertainment of exposure/treatment
No or not described
Follow-up complete and all patients included in the analysis?
Non-response unlikely to introduce bias (>80% in both cases and controls)
Size of effect
4 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
2 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

Jutta's tick icon.png Included



Comments

EMR + RFA superior to stepwise resection in terms of complications

Completed by

Professor Shan Rajendra MBBCh, MSc, MRCP. MD, FRCP, FRCPE, FRACP


Jutta's tick icon.png This appraisal has been completed.


Article
van Vilsteren FG, Pouw RE, Seewald S, Alvarez Herrero L, Sondermeijer CM, Visser M, et al. Stepwise radical endoscopic resection versus radiofrequency ablation for Barrett's oesophagus with high-grade dysplasia or early cancer: a multicentre randomised trial. Gut 2011 Jun;60(6):765-73 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21209124.
Assigned to
User:Darren.pavey
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment