Critical appraisal:Van der Burgh A, Dees J, Hop WC, van Blankenstein M 1996
van der Burgh A, Dees J, Hop WC, van Blankenstein M. Oesophageal cancer is an uncommon cause of death in patients with Barrett's oesophagus. Gut 1996 Jul;39(1):5-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/8881798.
prevalence and incidence study
|High risk of bias||Comments: Please replace this text and include any additional comments in regards to your quality rating|
Risk of bias assessment: prevalence and incidence study
- Highly selected (single institution) or not described
- Representative of eligible patients (consecutive or random sample e.g. states all patients recruited in given time frame)
- Objective and reliable (based on registry or other equivalent source)
- Reasonable follow-up (>80%)
During a mean follow up of 9.3 years (amounting to 1440 patient years) eight patients had developed oesophageal cancer at random intervals (one case in 180 patient years). All but one ofthe tumours were diagnosed at endoscopy for symptoms, three in the stage ofcarcinoma in situ. Risk factors for the development of oesophageal cancer were extensive Barrett's oesophagus exceeding 10 cm (p=002) and Barrett's ulcer at the time of intake (p=0.009).The patients of this cohort would not have benefited from an endoscopic surveillance programme.
- van der Burgh A, Dees J, Hop WC, van Blankenstein M. Oesophageal cancer is an uncommon cause of death in patients with Barrett's oesophagus. Gut 1996 Jul;39(1):5-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/8881798.
- Assigned to
- Topic area
- Clinical question
Section below only relevant for Cancer Council Project Officer