Critical appraisal:Van der Burgh A, Dees J, Hop WC, van Blankenstein M 1996

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Critical Appraisal

Article being appraised

van der Burgh A, Dees J, Hop WC, van Blankenstein M. Oesophageal cancer is an uncommon cause of death in patients with Barrett's oesophagus. Gut 1996 Jul;39(1):5-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/8881798.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

166


Includes an economic evaluation

no

Evidence ratings

Risk of bias
High risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: prevalence and incidence study

Source population of patients
Highly selected (single institution) or not described
Subject (sample) selection
Representative of eligible patients (consecutive or random sample e.g. states all patients recruited in given time frame)
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Reasonable follow-up (>80%)
Result of appraisal

Jutta's tick icon.png Included



Comments

During a mean follow up of 9.3 years (amounting to 1440 patient years) eight patients had developed oesophageal cancer at random intervals (one case in 180 patient years). All but one ofthe tumours were diagnosed at endoscopy for symptoms, three in the stage ofcarcinoma in situ. Risk factors for the development of oesophageal cancer were extensive Barrett's oesophagus exceeding 10 cm (p=002) and Barrett's ulcer at the time of intake (p=0.009).The patients of this cohort would not have benefited from an endoscopic surveillance programme.

Completed by

Erfan Jaberiyanfar


Jutta's tick icon.png This appraisal has been completed.


Article
van der Burgh A, Dees J, Hop WC, van Blankenstein M. Oesophageal cancer is an uncommon cause of death in patients with Barrett's oesophagus. Gut 1996 Jul;39(1):5-8 Available from: http://www.ncbi.nlm.nih.gov/pubmed/8881798.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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