Critical appraisal:Veenhof AA, Sietses C, von Blomberg BM, van Hoogstraten IM, vd Pas MH, Meijerink WJ, et al 2011

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Risk of bias assessment: Randomised Controlled Trial (Cochrane risk of bias tool)

Random sequence generation
Describe the method used to generate the allocation sequence in sufficient detail to allow an assessment of whether it should produce comparable groups.Jutta's question mark icon.png
Patients were then randomly assigned in a

2:1 ratio to laparoscopic surgery or open surgery in
accordance with a list of randomisation numbers and
treatment allocation. This list was com puter generated by
the trial statistician.

What was the risk of bias from the random sequence generation?Jutta's question mark icon.png
Low
Allocation concealment
Describe the method used to conceal the allocation sequence in sufficient detail to determine whether intervention allocations could have been foreseen in advance of or during, enrolment.Jutta's question mark icon.png
After eligibility had been established and patients provided

written informed consent, the local investigator registered
patients on the trial’s website to ensure allocation
concealment.

What was the risk of bias from the allocation concealment?Jutta's question mark icon.png
Unclear
Blinding
Describe all measures used, if any, to blind outcome assessors from knowledge of which intervention a participant received. Provide any information relating to whether the intended blinding was effective.Jutta's question mark icon.png
Blinding not described.
What was the risk of bias from the blinding of participants and personnel and outcome assessors?Jutta's question mark icon.png
Unclear
Incomplete outcome data
Describe the completeness of outcome data for each main outcome, including attrition and exlusions from the analysis. State whether attrition and exclusions were reported, the numbers in each intervention group (compared with total randomized participants), reasons for attrition/exclusions where reported, and any re-inclusions in analyses performed by the review authors.Jutta's question mark icon.png
All relevant participant data presented (n=40).
What was the risk of bias from incomplete outcome data?Jutta's question mark icon.png
Low
Selective outcome reporting
State how the possibility of selective outcome reporting was examined by the review authors and what was found.Jutta's question mark icon.png
All relevant outcomes reported in study protocol.
What was the risk of bias from selective outcome reporting? Assessments should be made for each main outcome (or class of outcomes).Jutta's question mark icon.png
Low
Other sources of bias
Describe any other sources of biasJutta's question mark icon.png
What was the risk of bias from other sources?Jutta's question mark icon.png
High
Overall risk of bias
Unclear risk of bias Additional comments: Please replace this text and include any additional comments in regards to your risk of bias rating


Jutta's tick icon.png This appraisal has been completed.


Article
Veenhof AA, Sietses C, von Blomberg BM, van Hoogstraten IM, vd Pas MH, Meijerink WJ, et al. The surgical stress response and postoperative immune function after laparoscopic or conventional total mesorectal excision in rectal cancer: a randomized trial. Int J Colorectal Dis 2011 Jan;26(1):53-9 Available from: http://www.ncbi.nlm.nih.gov/pubmed/20922542.
Assigned to
User:Ben.lee-bates
Topic area
Guidelines:Colorectal cancer
Clinical question
Form
Form:Quality appraisal rct-cochrane
Outcomes
Complications and morbidity

Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment