Critical appraisal:Verbeek RE, van Oijen MG, ten Kate FJ, Vleggaar FP, Schipper ME, Casparie MK, et al 2012

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Critical Appraisal

Article being appraised

Verbeek RE, van Oijen MG, ten Kate FJ, Vleggaar FP, Schipper ME, Casparie MK, et al. Surveillance and follow-up strategies in patients with high-grade dysplasia in Barrett's esophagus: a Dutch population-based study. Am J Gastroenterol 2012 Apr 1;107(4):534-42 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22270082.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

699


Includes an economic evaluation

no

Evidence ratings

Risk of bias
Low risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: prevalence and incidence study

Source population of patients
Population based
Subject (sample) selection
Representative of eligible patients (consecutive or random sample e.g. states all patients recruited in given time frame)
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Result of appraisal

Jutta's tick icon.png Included



Comments

Retrospective population based study based on pathology reports, examining 699 patients with HGD in BO and follow up data. The progression rates to cancer after dx of HGD stratified by management are severely confounded by indication, but some of the most useful information is that amongst the 326 pts undergoing surveillance with biopsies after HGD diagnosis, progression rate to cancer is 14.4 per 100 patient years, or 52% in total by end of follow up. Risk factors for progression are multifocality of HGD, older age, and no prioir surveillance. Clinical data are missing (like length of Barrett's, nodularity, meications etc).

Completed by

Dr Mark Appleyard MD FRACP MRCP MBBS BSc


Jutta's tick icon.png This appraisal has been completed.


Article
Verbeek RE, van Oijen MG, ten Kate FJ, Vleggaar FP, Schipper ME, Casparie MK, et al. Surveillance and follow-up strategies in patients with high-grade dysplasia in Barrett's esophagus: a Dutch population-based study. Am J Gastroenterol 2012 Apr 1;107(4):534-42 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22270082.
Assigned to
User:Mark.appleyard
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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