Critical appraisal:Wani S, Falk GW, Post J, Yerian L, Hall M, Wang A, et al 2011

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Critical Appraisal

Article being appraised

Wani S, Falk GW, Post J, Yerian L, Hall M, Wang A, et al. Risk factors for progression of low-grade dysplasia in patients with Barrett's esophagus. Gastroenterology 2011 Oct;141(4):1179-86, 1186.e1 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21723218.


Applicable clinical question

Key Facts

Study Design

prevalence and incidence study

Number of Patients:

210



Evidence ratings

Risk of bias
Moderate risk of bias Comments: Please replace this text and include any additional comments in regards to your quality rating

Risk of bias assessment: prevalence and incidence study

Source population of patients
Selected group (multiple institutions)
Subject (sample) selection
Selected group (debateable whether group is representative e.g. consecutive sample but extensive exclusion criteria)
Measurement of condition
Objective and reliable (based on registry or other equivalent source)
Follow-up complete and all patients included in the analysis?
Yes (follow-up >95%)
Result of appraisal

Jutta's tick icon.png Included



Comments

Of the 210 patients included in the study, 6 patients developed esphageal adenocarcinoma with a incidence rate of 0.44% per year (0.2-0.98). Mean FUP of 6.22 years for a total of 959.6 patient-years.

Completed by

Ms Qingwei Luo


Jutta's tick icon.png This appraisal has been completed.


Article
Wani S, Falk GW, Post J, Yerian L, Hall M, Wang A, et al. Risk factors for progression of low-grade dysplasia in patients with Barrett's esophagus. Gastroenterology 2011 Oct;141(4):1179-86, 1186.e1 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21723218.
Assigned to
User:Freddy.sitas
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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