Critical appraisal:Wasif N, Gray RJ, Pockaj BA 2011

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Critical Appraisal

Article being appraised

Wasif N, Gray RJ, Pockaj BA. Desmoplastic melanoma - the step-child in the melanoma family? J Surg Oncol 2011 Feb;103(2):158-62 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21259250.


Applicable clinical question

Key Facts

Study Design

cohort study

Study aims:

To study surgical management of the primary tumour as well as regional lymph nodes and to identify prognostic factors in patients with desmoplastic melanoma.

Number of Patients:

1735

All pts had DM.
Reported outcome(s):

overall survival

Results of outcome(s):

5-y overall survival for entire cohort was 65%.
5-y OS:
45% vs 60%, p=0.002; biopsy only vs simple excision
67% vs 60%, p=0.029; wide local excision vs simple excision
not significantly different between biopsy, simple excision and wide local excision

Includes an economic evaluation

no

Evidence ratings

Level of evidence

III-2

Risk of bias
Moderate risk of bias Comments: Please replace this text and include any additional comments in regards to your risk of bias rating

Risk of bias assessment: cohort study

Subject selection
"New technology" group
Selected group
Comparison group
Selected group
Comparability of groups on demographic characteristics and clinical features
Comparable
Measurement of outcomes
Outcome measures blind to technology used
No, but objective measures used
Same method of measurement used across comparison groups
Yes
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
Yes (follow-up >95%) or survival analysis using all patients
Size of effect
2 Reason for decision: Please replace this text and briefly describe the reasons for your rating
Relevance of evidence
1 Additional comments: Please replace this text and briefly describe the reasons for your rating
Result of appraisal

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Completed by

Cecilia Taing


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Article
Wasif N, Gray RJ, Pockaj BA. Desmoplastic melanoma - the step-child in the melanoma family? J Surg Oncol 2011 Feb;103(2):158-62 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21259250.
Assigned to
User:Cecilia.taing
Topic area
Guidelines:Melanoma
Clinical question
Form
Form:Critical appraisal


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