Critical appraisal:White RR, Avital I, Sofocleous CT, Brown KT, Brody LA, Covey A, et al 2007

From Cancer Guidelines Wiki

Risk of bias assessment: cohort study

Subject selection
"New technology" group
Highly selected or not described
Comparison group
Highly selected or not described
Comparability of groups on demographic characteristics and clinical features
Not comparable and not adjusted for differences
Measurement of outcomes
Outcome measures blind to technology used
No, but objective measures used
Same method of measurement used across comparison groups
Yes
Completeness of follow-up
Was follow-up complete and were all patients included in the analysis?
No or not described
Overall risk of bias
High risk of bias Additional comments: New technology - Very selective w. databases to get patient pool, v. specific

outcome measures blinded to technology - Relapse and retreatment and survival = quite unbiased outcome measures

follow up complete - True local tumor progression-free survival (PFS) at the ablation/resection site at 1 year was 96% in the Wedge group and 48% in the RFA group (P<0.01; Fig. 1 after a median follow-up, 68 and 17 months in surviving patients, respectively. Two-year true local tumor PFS was 88% in the Wedge group and 41% in the RFA group.

Does not disclose actual % of follow up at 2 years (if median follow-up 17 months RFA, we cannot determine if FU was two year as specified as primary outcome)


Jutta's tick icon.png This appraisal has been completed.


Article
White RR, Avital I, Sofocleous CT, Brown KT, Brody LA, Covey A, et al. Rates and patterns of recurrence for percutaneous radiofrequency ablation and open wedge resection for solitary colorectal liver metastasis. J Gastrointest Surg 2007 Mar;11(3):256-63 Available from: http://www.ncbi.nlm.nih.gov/pubmed/17458595.
Assigned to
User:Melissa.chow
Topic area
Guidelines:Colorectal cancer
Clinical question
Form
Form:Quality appraisal cohort


Section below only relevant for Cancer Council Project Officer

Edit appraisal assignment