Critical appraisal:Zhang L, Dong L, Liu J, Lu X, Zhang J 2009

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Critical Appraisal

Article being appraised

Zhang L, Dong L, Liu J, Lu X, Zhang J. Endoscopic ablation of Barrett's esophagus using the second generation argon plasma coagulation: a prospective randomized controlled trail. JNMU 2009;23(3):183-188.


Applicable clinical question

Key Facts

Study Design

randomised controlled trial

Number of Patients:

35


Includes an economic evaluation

no

Evidence ratings

Level of evidence

II

Risk of bias
High risk of bias Comments: Details of post ablation histology and endoscopic findings are limited

Risk of bias assessment: randomised controlled trial

Was the trial double-blinded?
Outcomes not blinded, substantial side-effects, or not reported.
Was the treatment allocation schedule concealed?
Adequately concealed (e.g. central randomisation, numbered or coded bottles, drugs prepared by pharmacy).
Were all randomised participants included in the analysis?
No exclusions or survival analysis used with all subjects included (>95% follow-up for all groups).
The field below is not considered when calculating the risk of bias rating
How was the allocation schedule generated?
Adequate (e.g. random number table, computer random generator, coin tossing, card shuffling)
Size of effect
1 Reason for decision: The treated group had a markedly and consistently different outcome compared to the placebo group.
Relevance of evidence
4 Additional comments: The study is a randomised controlled study but the number of patients included is low. In addition, ablation of non-dysplastic Barrett's mucosa to date has not been proven to prevent the risk of neoplastic progression and is presently not an accepted approach in standard Barrett's patients. Finally the study population is Chinese and the risk of neoplastic progression of Barrett's oesophagus may be different to Caucasians.
Result of appraisal

Jutta's tick icon.png Included




Completed by

Dr Mark Schoeman MBBS, PhD, FRACP, AGAF


Jutta's tick icon.png This appraisal has been completed.


Article
Zhang L, Dong L, Liu J, Lu X, Zhang J. Endoscopic ablation of Barrett's esophagus using the second generation argon plasma coagulation: a prospective randomized controlled trail. JNMU 2009;23(3):183-188.
Assigned to
User:Mark.schoeman
Topic area
Guidelines:Barrett's
Clinical question
Form
Form:Critical appraisal


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