Zhang L, Dong L, Liu J, Lu X, Zhang J. Endoscopic ablation of Barrett's esophagus using the second generation argon plasma coagulation: a prospective randomized controlled trail. JNMU 2009;23(3):183-188.
randomised controlled trial
|High risk of bias||Comments: Details of post ablation histology and endoscopic findings are limited|
Risk of bias assessment: randomised controlled trial
- Outcomes not blinded, substantial side-effects, or not reported.
- Adequately concealed (e.g. central randomisation, numbered or coded bottles, drugs prepared by pharmacy).
- No exclusions or survival analysis used with all subjects included (>95% follow-up for all groups).
The field below is not considered when calculating the risk of bias rating
|1||Reason for decision: The treated group had a markedly and consistently different outcome compared to the placebo group.|
|4||Additional comments: The study is a randomised controlled study but the number of patients included is low. In addition, ablation of non-dysplastic Barrett's mucosa to date has not been proven to prevent the risk of neoplastic progression and is presently not an accepted approach in standard Barrett's patients. Finally the study population is Chinese and the risk of neoplastic progression of Barrett's oesophagus may be different to Caucasians.|
- Zhang L, Dong L, Liu J, Lu X, Zhang J. Endoscopic ablation of Barrett's esophagus using the second generation argon plasma coagulation: a prospective randomized controlled trail. JNMU 2009;23(3):183-188.
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- Topic area
- Clinical question
Section below only relevant for Cancer Council Project Officer