Advances in technique

From Cancer Guidelines Wiki


Background

In addition to technological improvements in colonoscope design and adjunctive technologies, various techniques have been evaluated to improve the performance of colonoscopy for the detection of colorectal neoplasia and reduce the operator dependence of colonoscopy. These techniques are intended to assist in exposing hidden mucosa, and complement those technologies that can assist in highlighting and improving the recognition of mucosal lesions.

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Overview of evidence (non-systematic literature review)

No systematic reviews were undertaken for this topic. Practice points were based on selected evidence and guidelines (see Guideline development process).

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Instrument insertion

Water exchange/immersion

Water exchange is the technique of filling the colon with clean water during instrument insertion, while simultaneously removing dirty water. Several studies have shown that the improvement in quality of bowel preparation achieved through this technique is associated with improved adenoma detection rates. An infusion volume of at least 500mL appears necessary.[1] Water exchange does, however, increase procedure time by prolonging the insertion time to caecum.[1]Back to top

Instrument withdrawal

Mucosal inspection technique

ColonoscopyAn examination of the large bowel using a camera on a flexible tube, which is passed through the anus. is a highly operator-dependent procedure. The magnitude of the difference in adenoma detection between high- and low-detector endoscopists in the same practice context far exceeds the improvements seen from technological adjuncts or advances in colonoscopy.

ColonoscopyAn examination of the large bowel using a camera on a flexible tube, which is passed through the anus. fundamentally requires deliberate and systematic interrogation of the colorectal mucosa. The technique for mucosal inspection that has been shown to be associated with improved detection involves:

  • systematic deflection of the instrument tip during withdrawal to scrutinise the proximal surfaces of colonic folds, flexures and valves
  • intensive washing and suctioning of residual debris and pools and fluid
  • adequate luminal distension.[2]

Intraprocedural cleansing of the colon is essential to achieve high rates of adequate preparation, with reported mean washing times of over 4 minutes.[3]

Both external review of technique (by videorecording[4]) or audit of detection performance[5] are known to motivate improvements in detection. Training in mucosal inspection behaviours and in lesion recognition improves adenoma detection.[6][7][8]Back to top

Withdrawal time

The importance of withdrawal time for high quality colonoscopy has been over-emphasised after the initial landmark study demonstrating an association between longer withdrawal time and adenoma detection rates.[9] While effective inspection of the colorectal mucosa takes time merely increasing the time taken is not the required behaviour. Rather, effective detection requires meticulous mucosal exposure technique together with recognition of neoplastic lesions. Institutional policies of forced withdrawal time targets have not been successful,[10] unless combined with education and timed segmental inspection targets.[11] Withdrawal time remains only a surrogate indicator of those mucosal inspection behaviours required for neoplasia detection.

Proximal colon examination

Observational studies from the USAUnited States of America and Germany have consistently shown lower levels of protection against cancer in the right colon/proximal colon (ie proximal to the splenic flexure).[12][13][14][15] Studies have examined the benefit of instrument retroflexion in the proximal colon, performed after an initial inspection from the caecum to the hepatic flexure in the forward view. Retroflexion is possible in the right colon in over 90% of patients,[16] although randomised controlled trials have shown that a second forward-view examination of the proximal colon is as effective for additional polyp detection as a second examination in retroflexion.[17][18] The yield of a second right colon examination is higher when polyps have been found on the forward view, and in patients who are older, male or have bleeding indications.[16]Back to top

PolypA small growth protruding from a mucous membrane, such as the lining of the bowel. size estimation

Once detected, polyps should be assessed prior to resection. Assessment should include documentation of the location, size and morphology of the lesion. Accurate measurement of polyp size is important for the determination of appropriate surveillance intervals.

Endoscopic measurement of polyp size is limited by human and technology bias. Endoscopists are known to be influenced by terminal digit preference for 'pleasing' numbers.[ref] The fish-eye lens of colonoscopes causes distortion in which objects in the centre of the display appear magnified, while objects at the periphery appear smaller and warped.[19][20] Furthermore, the two-dimensional display creates a lack of depth awareness.

Accuracy of polyp measurement can be improved by the use of reference cues, such as comparison of the lesion with a device of known dimensions (e.g. the tip of a snare catheter or an open snare wire).[20] To mitigate against technology bias and minimise visual size illusions, the lesion should be touching the measurement device and kept in the centre of the display.


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Routine polypectomy

The protective effect of colonoscopy on colorectal cancer incidence derives from the detection and removal of precancerous lesions.[21] PolypectomyThe removal of polyps from the bowel. is therefore central to the practice of colonoscopy. However, like other aspects of colonoscopy practice, is highly operator dependent. Up to 27% of interval cancers may be due to incomplete endoscopic resection,[21] and rates of incomplete hot snare resection of nonpedunculated neoplastic polyps vary significantly between endoscopists within a reported range of 6.5% to 22.7%.[22]

Cold snare polypectomy has become the standard of care for diminutive (1–5mm) colorectal polyps and is the recommended technique in international guidelines for sessile polyps ≤9mm.[23] Cold snaring is more effective and efficient than cold forceps resection and is virtually without risk. Cold biopsy forceps should be avoided because of high rates of incomplete resection.[23]

The major benefit of cold snare techniques is safety, by avoiding the risk of thermal mural injury that is associated with post-polypectomy syndrome, perforation and delayed bleeding. Hot biopsy forceps are associated with unacceptably high rates of deep thermal injury but also incomplete resection, and should not be used.[23] Because immediate bleeding can be visualised and treated, cold techniques can even be used safely in patients taking antiplatelet agents and anticoagulants.[24]

Large (≥20mm) sessile and laterally-spreading polyps can increasingly be removed endoscopically, rather than with surgical resection. Patients with these lesions should be referred to centres with expertise in advanced colonoscopic resection techniques.[23]Back to top

Practice Points

Practice pointA recommendation on a subject that is outside the scope of the search strategy for the systematic review, based on expert opinion and formulated by a consensus process.Question mark transparent.png

Fundamental colonoscopic inspection technique should ensure systematic exposure of the proximal sides of folds and flexures, intensive intraprocedural cleansing and adequate distension of the colon.

Practice pointA recommendation on a subject that is outside the scope of the search strategy for the systematic review, based on expert opinion and formulated by a consensus process.Question mark transparent.png

Colonoscopists should undergo training in the fundamentals of mucosal exposure and inspection techniques, and in the endoscopic appearance of adenomas and serrated lesions to increase detection rates and improve clinical outcomes of colonoscopy.

Practice pointA recommendation on a subject that is outside the scope of the search strategy for the systematic review, based on expert opinion and formulated by a consensus process.Question mark transparent.png

Water exchange should be considered to improve adenoma detection through an effect on mucosal cleansing and higher rates of adequate bowel preparation.

Practice pointA recommendation on a subject that is outside the scope of the search strategy for the systematic review, based on expert opinion and formulated by a consensus process.Question mark transparent.png

A second examination of the proximal colon in either the forward view or in retroflexion is recommended to improve lesion detection, particularly in patients with an expected higher prevalence of neoplasia.

Practice pointA recommendation on a subject that is outside the scope of the search strategy for the systematic review, based on expert opinion and formulated by a consensus process.Question mark transparent.png

Sessile polyps under 10mm in size should be removed using cold snare polypectomy. This is preferred over hot snare, which is unnecessary in most situations. Hot biopsy forceps should not be used because they are associated with unacceptably high rates of incomplete resection and deep mural injury.

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References

  1. 1.01.1 Cadoni S, Falt P, Rondonotti E, Radaelli F, Fojtik P, Gallittu P, et al. Water exchange for screening colonoscopy increases adenoma detection rate: a multicenter, double-blinded, randomized controlled trial. Endoscopy 2017 May;49(5):456-467 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/28282689.
  2. Rex DK. Colonoscopic withdrawal technique is associated with adenoma miss rates. Gastrointest Endosc 2000 Jan;51(1):33-6 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/10625792.
  3. MacPhail ME, Hardacker KA, Tiwari A, Vemulapalli KC, Rex DK. Intraprocedural cleansing work during colonoscopy and achievable rates of adequate preparation in an open-access endoscopy unit. Gastrointest Endosc 2015 Mar;81(3):525-30 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/24998464.
  4. Rex DK, Hewett DG, Raghavendra M, Chalasani N. The impact of videorecording on the quality of colonoscopy performance: a pilot study. Am J Gastroenterol 2010 Nov;105(11):2312-7 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21048675.
  5. Kahi CJ, Ballard D, Shah AS, Mears R, Johnson CS. Impact of a quarterly report card on colonoscopy quality measures. Gastrointest Endosc 2013 Jun;77(6):925-31 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/23472996.
  6. Coe SG, Crook JE, Diehl NN, Wallace MB. An endoscopic quality improvement program improves detection of colorectal adenomas. Am J Gastroenterol 2013 Feb;108(2):219-26; quiz 227 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/23295274.
  7. Kaminski MF, Anderson J, Valori R, Kraszewska E, Rupinski M, Pachlewski J, et al. Leadership training to improve adenoma detection rate in screening colonoscopy: a randomised trial. Gut 2016 Apr;65(4):616-24 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/25670810.
  8. Wallace MB, Crook JE, Thomas CS, Staggs E, Parker L, Rex DK. Effect of an endoscopic quality improvement program on adenoma detection rates: a multicenter cluster-randomized controlled trial in a clinical practice setting (EQUIP-3). Gastrointest Endosc 2017 Mar;85(3):538-545.e4 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/27473182.
  9. Barclay RL, Vicari JJ, Doughty AS, Johanson JF, Greenlaw RL. Colonoscopic withdrawal times and adenoma detection during screening colonoscopy. N Engl J Med 2006 Dec 14;355(24):2533-41 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/17167136.
  10. Sawhney MS, Cury MS, Neeman N, Ngo LH, Lewis JM, Chuttani R, et al. Effect of institution-wide policy of colonoscopy withdrawal time > or = 7 minutes on polyp detection. Gastroenterology 2008 Dec;135(6):1892-8 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/18835390.
  11. Barclay RL, Vicari JJ, Greenlaw RL. Effect of a time-dependent colonoscopic withdrawal protocol on adenoma detection during screening colonoscopy. Clin Gastroenterol Hepatol 2008 Oct;6(10):1091-8 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/18639495.
  12. Brenner H, Chang-Claude J, Seiler CM, Rickert A, Hoffmeister M. Protection from colorectal cancer after colonoscopy: a population-based, case-control study. Ann Intern Med 2011 Jan 4;154(1):22-30 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21200035.
  13. Baxter NN, Warren JL, Barrett MJ, Stukel TA, Doria-Rose VP. Association between colonoscopy and colorectal cancer mortality in a US cohort according to site of cancer and colonoscopist specialty. J Clin Oncol 2012 Jul 20;30(21):2664-9 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/22689809.
  14. Nishihara R, Wu K, Lochhead P, Morikawa T, Liao X, Qian ZR, et al. Long-term colorectal-cancer incidence and mortality after lower endoscopy. N Engl J Med 2013 Sep 19;369(12):1095-105 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/24047059.
  15. Doubeni CAConventional adenoma, Weinmann S, Adams K, Kamineni A, Buist DS, Ash AS, et al. Screening colonoscopy and risk for incident late-stage colorectal cancer diagnosis in average-risk adults: a nested case-control study. Ann Intern Med 2013 Mar 5;158(5 Pt 1):312-20 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/23460054.
  16. 16.016.1 Hewett DG, Rex DK. Miss rate of right-sided colon examination during colonoscopy defined by retroflexion: an observational study. Gastrointest Endosc 2011 Aug;74(2):246-52 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/21679946.
  17. Harrison M, Singh N, Rex DK. Impact of proximal colon retroflexion on adenoma miss rates. Am J Gastroenterol 2004 Mar;99(3):519-22 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/15056095.
  18. Kushnir VM, Oh YS, Hollander T, Chen CH, Sayuk GS, Davidson N, et al. Impact of retroflexion vs. second forward view examination of the right colon on adenoma detection: a comparison study. Am J Gastroenterol 2015 Mar;110(3):415-22 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/25732415.
  19. Plumb AA, Nickerson C, Wooldrage K, Bassett P, Taylor SA, Altman D, et al. Terminal digit preference biases polyp size measurements at endoscopy, computed tomographic colonography, and histopathology. Endoscopy 2016 Oct;48(10):899-908 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/27441685.
  20. 20.020.1 Sakata S, Klein K, Stevenson ARL, Hewett DG. Measurement Bias of Polyp Size at Colonoscopy. Dis ColonThe main part of the large bowel, which absorbs water and electrolytes from undigested food (solid waste). Its four parts are the ascending colon, transverse colon, descending colon and sigmoid colon. RectumThe final section of the large bowel, ending at the anus. 2017 Sep;60(9):987-991 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/28796738.
  21. 21.021.1 Hewett DG, Rex DK. The big picture: does colonoscopy work? Gastrointest Endosc Clin N Am 2015 Apr;25(2):403-13 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/25839693.
  22. Pohl H, Srivastava A, Bensen SPSerrated polyp, Anderson P, Rothstein RI, Gordon SR, et al. Incomplete polyp resection during colonoscopy-results of the complete adenoma resection (CARE) study. Gastroenterology 2013 Jan;144(1):74-80.e1 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/23022496.
  23. 23.023.123.223.3 Ferlitsch M, Moss A, Hassan C, Bhandari P, Dumonceau JM, Paspatis G, et al. Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy 2017 Mar;49(3):270-297 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/28212588.
  24. Horiuchi A, Nakayama Y, Kajiyama M, Tanaka N, Sano K, Graham DY. Removal of small colorectal polyps in anticoagulated patients: a prospective randomized comparison of cold snare and conventional polypectomy. Gastrointest Endosc 2014 Mar;79(3):417-23 Abstract available at http://www.ncbi.nlm.nih.gov/pubmed/24125514.

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