Colorectal cancer

Discussion

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Dr Louise Nott BMedSci MBBS.Hons FRACP, Dr Muhammad Khattak, Professor Timothy Price MBBS, DHlthSc (Medicine), FRACP, Dr Amanda Townsend, Cancer Council Australia Colorectal Cancer Guidelines Working Party. Guidelines:Colorectal cancer/Discussion Management non resectable recurrent metastatic CRC . In: Clinical practice guidelines for the prevention, early detection and management of colorectal cancer. Sydney: Cancer Council Australia. [Version URL: https://wiki.cancer.org.au/australiawiki/index.php?oldid=173111, cited 2023 Jun 1]. Available from: https://wiki.cancer.org.au/australia/Guidelines:Colorectal_cancer.


Last modified:
7 November 2017 23:42:40





Discussion[edit source]

Studies currently underway[edit source]

The combined overall survival analysis of the three first-line studies, SIRFLOX, FOXFIRE and FOXFIRE Global are planned for 2017 will hopefully give clinicians guidance as to the role of SIRT in chemo-naive patients and the current guidelines will be updated when this information is available::

  • SIRFLOX (NCT00724503): a randomised multicentre trial comparing SIRFLOX - FOLFOX plus SIR-SPHERES MICROSPHERES vs. FOLFOX alone in patients with liver metastases from primary colorectal cancer.
  • FOXFIRE (ISRCTN83867919): an open-label randomised phase III trial of 5-Fluorouracil, Oxaliplatin and Folinic acid +/- Interventional Radio-Embolisation as first line treatment for patients with unresectable liver-only or liver-predominant metastatic colorectal cancer.
  • FOXFIRE Global (NCT01721954): a randomised multicentre trial comparing FOLFOX6m Plus SIR-Spheres Microspheres vs FOLFOX6m Alone in patients with liver metastases from primary colorectal cancer.

It has been hypothesized that pulmonary metastases may behave in a more indolent fashion and control of hepatic metastases will therefore improve survival, however, this question will not be answered until the overall survival results are presented (in combination with FOXFIRE and FOXFIRE Global studies).

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Referring to the large bowel, comprising the colon and rectum.

Systemic chemotherapy using a combination of the drugs Leucovorin (folinic acid), Fluorouracil, and Oxaliplatin.

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