Colorectal cancer

Introduction
Summary of recommendations
Plain-language summary
Colorectal cancer in Australia
Primary prevention
- Introduction: primary prevention
- Dietary and lifestyle strategies
- Chemopreventive candidate agents
Population screening for colorectal cancer
- Introduction: population screening for colorectal cancer
- Evidence: Population screening for CRC
- Evidence summary, recommendations and considerations
- Discussion
The symptomatic patient
- Introduction: the symptomatic patient
- Signs & symptoms predictive of CRC
- Optimal max time from referral to diagnosis and treatment
Risk and screening based on family history
- Introduction: Risk and screening based on family history
- Colorectal cancer risk according to family history (FHS2)
- Screening strategies for people with a family history of colorectal cancer
High-risk familial syndromes
- Introduction: high-risk familial syndromes
- Familial adenomatous polyposis
- MUTYH associated polyposis
- Lynch syndrome
- Peutz-Jeghers syndrome
- Juvenile polyposis syndrome
- Serrated polyposis syndrome
- Supplement. State- and territory-based familial cancer registries
Imaging a patient with a diagnosis of CRC
- Colon cancer
- Rectal cancer
- Addenda: rectal MRI cancer report
Pathology and staging
- Introduction: pathology and staging
- Development of post-surgical staging
- Post-surgical staging following neoadjuvant therapy
- Clinicopathological staging systems
- Selection of staging system
- Clinical input
- Additional information on pathology reporting
- Optimal molecular profiling of CRC
Preparation for surgery and perioperative optimisation
- Introduction: preparation for surgery and perioperative optimisation
- MDT meetings
- Perioperative anaemia management
- Thromboembolic prophylaxis
- Nutritional interventions
- Stomal therapy
- Body temperature
- Enhanced recovery after surgery
- Mechanical bowel prep and antibiotic prophylaxis
Elective and emergency surgery for colon and rectal cancer
- Optimal approach to elective resection for colon cancers (COL1-2a)
- Optimal approach to elective resection for rectal cancers
- Emergency management of malignant large bowel obstruction (COLMNG5)
- Peritonectomy with hyperthermic intraperitoneal chemotherapy (COLMNG3)
Adjuvant therapy for colon cancer
- Introduction: adjuvant therapy for colon cancer
- Adjuvant therapy for stage III colon
  - Adjuvant therapy for stage III colon
  - Adjuvant therapy for elderly stage III CRC (ADJ1)
- Adjuvant therapy for stage II colon
  - Adjuvant therapy for stage II colon
- Irinotecan and targeted agents (Stage II-III colon)
- Discussion
Neoadjuvant & adjuvant therapy for rectal cancer
- Introduction: neoadjuvant & adjuvant therapy for rectal cancer
- Neoadjuvant therapy for rectal cancer
- 'Watch and wait' approach after clinical complete response to neoadjuvant chemoradiation
- Neoadjuvant chemotherapy regimen
- Optimal timing surgery after neoadjuvant therapy
- Adjuvant therapy for rectal cancer
- Discussion
Management resectable locally recurrent and metastatic disease
- Introduction: management resectable locally recurrent and metastatic disease
- Investigation of recurrent colorectal cancer
- Management of recurrent, resectable CRC (MNG13)
- Management of metastatic resectable CRC (MNG14)
Management non-resectable locally recurrent and metastatic disease
- Introduction: management of non resectable recurrent metastatic CRC
- Synchronous primary in metastatic CRC
- Discussion
Role systemic therapies in non-resectable metastatic CRC
- Introduction: role systemic therapies in non-resectable metastatic CRC
- Molecular pathology and biomarkers for systemic therapy
- Biological agents in first-line tx of metastatic CRC
- Subsequent treatment & continuum-of-care model
- Systemic second-line treatment
- Systemic third-line treatment
- Supportive care options
Follow-up after curative resection for CRC
- Introduction: follow-up after curative resection for CRC
- Rationale for follow-up
- Optimal follow-up surveillance protocol (FUR1-2)
- Health professionals performing follow-up & suggested schedule
Psychosocial care
Appendices
- Guideline development process
- Clinical question list
- Journal articles
- Technical report
- Additional resources
- Glossary and abbreviations
- Working party members & contributors
- Project team contributions
- Conflict of interest register

Population screening evidence

From Cancer Guidelines Wiki

Clinical practice guidelines for the prevention, early detection and management of colorectal cancer > Population screening evidence

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Systematic reviews and modelling were performed to determine:

the benefit of screening with various modalities (PSC1a)

test accuracy (PSC1b)

the cost-effectiveness of population screening using various strategies (PSC1c)

the optimal target age range for population screening (PSC1d).

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