11. Organ transplantation and other conditions associated with immunosuppression
Susceptibility to keratinocyte cancers (KCs) is increased by conditions or drugs that dysregulate or suppress the immune system. Affected patients include people with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV-AIDS), people with chronic lymphocytic leukaemia (CLL) and organ transplant recipients treated with immunosuppressant drugs.
The management of KCs can be difficult in patients who have been immunosuppressed for many years and are at especially high risk of KCs due to high tumour load. The care of these people is best provided in multidisciplinary specialist care settings, where a combination of specific strategies can be used to reduce the KC burden.
Topics covered in this section include:
- Epidemiology of keratinocyte cancers in immunosuppressed patients
- Management of keratinocyte cancer risk in organ transplant recipients
- Strategies to manage keratinocyte cancer in organ transplant recipients
- Organ transplantation and other conditions associated with immunosuppression – Health system implications and discussion