5. Pathology of keratinocyte cancer

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Clinical practice guidelines for keratinocyte cancer > 5. Pathology of keratinocyte cancer


Keratinocytic tumours form a wide continuum from benign tumours to malignant tumours. This spectrum includes:

  • benign adnexal tumours, often showing follicular differentiation
  • tumours of intermediate malignant potential, such as keratoacanthoma (which usually resolve)
  • pre-invasive lesions, such as Bowen’s diseasecSCC in situ (also known as intra-epidermal SCC) (cutaneous squamous cell carcinoma in situ) and actinic keratosis
  • frankly malignant tumours, such as basal cell carcinoma and cutaneous squamous cell carcinoma
  • rare tumours, such as Merkel cell carcinoma, Paget’s disease and atypical fibroxanthoma.

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