Melanoma

Treatment of brain metastases in patients with melanoma

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Clinical practice guidelines for the diagnosis and management of melanoma > Treatment of brain metastases in patients with melanoma


Guideline contents > [[Guidelines:Melanoma/Treatment approaches to brain metastases for patients with advanced melanoma|]]

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Melanoma Institute Australia

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Long G, Dr Brindha Shivalingam, Associate Professor Matteo Carlino, Clinical Professor Angela Hong, Dr Victoria Atkinson, Kefford, R, McArthur, G, Dr. Alexander Menzies, Cancer Council Australia Melanoma Guidelines Working Party. Guidelines:Melanoma/Treatment approaches to brain metastases for patients with advanced melanoma . In: Clinical practice guidelines for the diagnosis and management of melanoma. Sydney: Melanoma Institute Australia. [Version URL: https://wiki.cancer.org.au/australiawiki/index.php?oldid=199465, cited 2023 Jun 1]. Available from: https://wiki.cancer.org.au/australia/Guidelines:Melanoma.


Last modified:
7 March 2019 05:46:10





Melanoma has a high propensity to metastasise to the brain. Up to 50% of patients with stage IV disease will develop brain metastases during the course of their illness (25% of patients have them at initial diagnosis of stage IV)[1] and these are associated with a poor prognosis, with a median overall survival (OS) of 2.8 to 4 months.[2][3][4] Control of brain metastases is important since its progression often leads to deterioration in neurological function and quality of life and/or neurologic death.

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References

  1. ↑ Jakob JA, Bassett RL Jr, Ng CS, Curry JL, Joseph RW, Alvarado GC, et al. NRAS mutation status is an independent prognostic factor in metastatic melanoma. Cancer 2012 Aug 15;118(16):4014-23 Available from: http://www.ncbi.nlm.nih.gov/pubmed/22180178.
  2. ↑ Davies MA, Liu P, McIntyre S, Kim KB, Papadopoulos N, Hwu WJ, et al. Prognostic factors for survival in melanoma patients with brain metastases. Cancer 2011 Apr 15;117(8):1687-96 Available from: http://www.ncbi.nlm.nih.gov/pubmed/20960525.
  3. ↑ Fife KM, Colman MH, Stevens GN, Firth IC, Moon D, Shannon KF, et al. Determinants of outcome in melanoma patients with cerebral metastases. J Clin Oncol 2004 Apr 1;22(7):1293-300 Available from: http://www.ncbi.nlm.nih.gov/pubmed/15051777.
  4. ↑ Chiarion-Sileni V, Guida M, Ridolfi L, Romanini A, Del Bianco P, Pigozzo J, et al. Central nervous system failure in melanoma patients: results of a randomised, multicentre phase 3 study of temozolomide- and dacarbazine- based regimens. Br J Cancer 2011 Jun 7;104(12):1816-21 Available from: http://www.ncbi.nlm.nih.gov/pubmed/21610711.

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