Treatment of brain metastases in patients with melanoma

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Clinical practice guidelines for the diagnosis and management of melanoma > Treatment of brain metastases in patients with melanoma

Melanoma has a high propensity to metastasise to the brain. Up to 50% of patients with stage IV disease will develop brain metastases during the course of their illness (25% of patients have them at initial diagnosis of stage IV)[1] and these are associated with a poor prognosis, with a median overall survival (OS) of 2.8 to 4 months.[2][3][4] Control of brain metastases is important since its progression often leads to deterioration in neurological function and quality of life and/or neurologic death.

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  1. Jakob JA, Bassett RL Jr, Ng CS, Curry JL, Joseph RW, Alvarado GC, et al. NRAS mutation status is an independent prognostic factor in metastatic melanoma. Cancer 2012 Aug 15;118(16):4014-23 Available from:
  2. Davies MA, Liu P, McIntyre S, Kim KB, Papadopoulos N, Hwu WJ, et al. Prognostic factors for survival in melanoma patients with brain metastases. Cancer 2011 Apr 15;117(8):1687-96 Available from:
  3. Fife KM, Colman MH, Stevens GN, Firth IC, Moon D, Shannon KF, et al. Determinants of outcome in melanoma patients with cerebral metastases. J Clin Oncol 2004 Apr 1;22(7):1293-300 Available from:
  4. Chiarion-Sileni V, Guida M, Ridolfi L, Romanini A, Del Bianco P, Pigozzo J, et al. Central nervous system failure in melanoma patients: results of a randomised, multicentre phase 3 study of temozolomide- and dacarbazine- based regimens. Br J Cancer 2011 Jun 7;104(12):1816-21 Available from:

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