Public comments - Histopathology/Standards for classification, staging and grading

From Cancer Guidelines Wiki

Instructions for providing comments[edit source]

Click “Reply” in the bottom right corner and an empty comment box will open. The exact wording of your comment will appear in the discussion thread, but cannot be edited by other reviewers.

1) Please include your name and organisation to enable us to contact you if we need to clarify your comments. For privacy you may prefer not to enter your email address.

2) Copy and paste the sentence/paragraph to which your feedback relates, leave a blank line and then include your comment or suggested change.

3) Statements regarding the inclusion/exclusion of issues should be clearly supported by scientific evidence, and specifically outline the relevance of the suggested material to the guidelines.

Full citation of the reference/s should be provided for consideration.

4) If you have identified any gaps or errors in the content please suggest suitable text for inclusion.

5) Please highlight any terms that need to be defined in the Glossary.


For detailed help menu: Orange question mark.png

Jutta von Dincklage14:01, 11 February 2011

Update this section light of WHO Classification of Digestive Tumours, clarifies alignment of ENETS and WHO classifications. Commentary on reference to ICDO codes might be useful for individuals who code this for the registry . also it is important for the terminology to be clarified e.g NET G1, NET G2, NEC, etc (W Liauw), 10 March 2011

Amanda Charlton, The Children's Hospital at Westmead.

'Standards for classification, staging and grading [8, 9] The World Health Organization (WHO) classification attempts to separate NETs into behavioural categories according to size, depth of invasion and the presence or absence of angioinvasion. This is the most widely used classification system, and should be used in the reporting of NETs until a more definitive classification becomes available. It should be borne in mind that the general principles of the WHO vary for NETs from different sites.

The WHO classification however, does not address the ‘in between’ NETs that are less than well differentiated but are not poorly differentiated and that show an intermediate mitotic rate between low and high.'

I agree with w Liauw above that update is required, the WHO 2010 Classification of tumours of the Digestive system specifically addresses the grading and the "in betweens " into a NET G1, NET G2, NET G3 as explained in a special section in WHO book page 13 and 14., 19 July 2011