Public comments - Radionuclide Therapy/Lutetium-177 octreotate radiopeptide therapy of GEP-NETs

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Jutta von Dincklage14:56, 11 February 2011

It is hoped that 177Lu-octreotate will shortly become available on more favourable terms through the Australian Nuclear Science and Technology Organisation (ANSTO).

ANSTO has recently announced an agreement to import 177Lu from a German company, but unfortunately at an even greater cost than from IDB. It will be a few years before ANSTO is producing and selling its own 177Lu.

Richard Smart St George Hospital, Kogarah r.smart@unsw.edu.au

121.44.230.7821:50, 1 June 2011
 

COSA on behalf of Gabrielle Cehic and Steven Unger (Flinders Medical Centre, SA)

  • reference centres

Comment: Should this read: referral centres.

  • It is planned that patients with progressive, disseminated, unresectable, low grade GEP-NETs, with appropriate somatostatin receptor avidity demonstrated on diagnostic somatostatin receptor imaging, including 111In-Octreotide SPECT or 68Ga-somatostatin analogue PET studies, will be referred to the State reference centre for radiopeptide treatment.

Comment: Recommend adding Lutetium-177 Octreotide SPECT as a third indicator.

  • 177LuCl3 is commercially available to Australasian patients directly imported from Europe (IDB, Baarle-Nassau, NL). It is hoped that 177Lu-octreotate will shortly become available on more favourable terms through the Australian Nuclear Science and Technology Organisation (ANSTO). The use of identified reference centres would facilitate both gathering of data and national randomised controlled trials using 177Lu-octreotate, with or without radiosensitising chemotherapy.

Comment: A consistent reliable source is needed (i.e. IDB). ANSTO will not be producing sufficient quantity anywhere in the near future, and is likely to be very expensive.

Rhonda Cousins11:09, 26 July 2011