Public comments - Radionuclide Therapy/Patient selection

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Jutta von Dincklage14:54, 11 February 2011

COSA on behalf of Gabrielle Cehic and Steven Unger (Flinders Medical Centre, SA)

  • A prerequisite is the need to demonstrate that known tumour sites have sufficient uptake of diagnostic 111In-Octreotide or 68Ga-labelled somatostatin analogues, to indicate that therapeutic levels of internal radiation could be potentially delivered by administration of 177Lu-octreotate radiopeptide therapy.

Comment: Recommend also adding Lutetium-177 Octreotide SPECT for scanning.

  • Patients with clinically symptomatic residual disease following surgical debulking can reasonably be offered radiopeptide therapy. However, in the absence of symptoms or progressive disease, such treatment should only be offered in the setting of a clinical trial.

Comment: The final line recommends therapy only as part of a clinical trial. Given the lack of suitable alternatives and proven safety, consider rewording to cover use outside of a clinical trial (i.e. similar to compassionate use described under “Access to radiopeptide therapy in Australasia”).

Rhonda Cousins11:15, 26 July 2011