From Oncology for Medical Students

Objective 2.2

At graduation, the student should be able to describe the principles of handling of chemicals (by cells): drug metabolism, handling of carcinogens.

Prerequisite knowledge

  • Cell biology
  • Organ function
  • Normal physiology

Representative questions that suggest the required depth of knowledge

1. What is the blood/brain barrier?

Essential in answer:

  • Concept of sanctuary sites
  • Knowledge of mechanisms of fat solubility and molecular size

2. In a cancer patient with renal impairment, chemotherapy doses should be (select the best answer):

(a) decreased

(b) increased

(c) unchanged

(d) reviewed

Answer: (d)